PROTEIN CRYSTALLIZATION

Studies of the fundamental processes that underlie:

Issues addressed:

Why some protein crystals grow better in space?

First system-dependent rationale for advantages and disadvantages of reduced gravity for protein crystal perfection Improvement Expected

Crystallization and aggregation of human hemoglobin

Causes sickle cell and other related anemia; 800,000 in USA affected

First molecular resolution image of a hemoglobin crystal surface

Hemoglobin Crystal Surface
Visualization of elementary crystallization acts

Molecular resolution
Growth sites at steps
Impurity adsorption
Defects

Crystallization Steps